Defiant Bloodlord

Flying
Whenever you gain life, target opponent loses that much life.

Epicure of Blood

Whenever you gain life, each opponent loses 1 life.

Feed the Swarm

Destroy target creature or enchantment an opponent controls. You lose life equal to that permanent's mana value.

Greed

Infernal Offering

Choose an opponent. You and that player each sacrifice a creature. Each player who sacrificed a creature this way draws two cards.
Choose an opponent. Return a creature card from your graveyard to the battlefield, then that player returns a creature card from their graveyard to the battlefield.

Necropolis Regent

Flying
Whenever a creature you control deals combat damage to a player, put that many +1/+1 counters on it.

Noxious Gearhulk

Menace
When this creature enters, you may destroy another target creature. If a creature is destroyed this way, you gain life equal to its toughness.

Ob Nixilis Reignited

Ob Nixilis Reignited Emblem

+1: You draw a card and you lose 1 life.
−3: Destroy target creature.
−8: Target opponent gets an emblem with "Whenever a player draws a card, you lose 2 life."

Digsite Engineer

Construct

Whenever you cast an artifact spell, you may pay {2}. If you do, create a 0/0 colorless Construct artifact creature token with "This token gets +1/+1 for each artifact you control."

Parasitic Impetus

Enchant creature
Enchanted creature gets +2/+2 and is goaded. (It attacks each combat if able and attacks a player other than you if able.)
Whenever enchanted creature attacks, its controller loses 2 life and you gain 2 life.

Reckless Spite

Destroy two target nonblack creatures. You lose 5 life.

Sangromancer

Flying
Whenever a creature an opponent controls dies, you may gain 3 life.
Whenever an opponent discards a card, you may gain 3 life.

Sanguine Soothsayer

Sanguine Bond

Whenever you gain life, target opponent loses that much life.

Silversmote Ghoul

At the beginning of your end step, if you gained 3 or more life this turn, return this card from your graveyard to the battlefield tapped.
{1}{B}, Sacrifice this creature: Draw a card.

Suffer the Past

Exile X target cards from target player's graveyard. For each card exiled this way, that player loses 1 life and you gain 1 life.

Food

Taste of Death

Each player sacrifices three creatures of their choice. You create three Food tokens. (They're artifacts with "{2}, {T}, Sacrifice this token: You gain 3 life.")

Commander 2021